Virtual pacing of a patient's digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy.
Tijmen KoopsenWillem GerritsNick van OstaTim van LoonPhilippe C WoutersFrits W PrinzenKevin VernooyTammo DelhaasArco J TeskeMathias MeineMaarten J CramerJoost LumensPublished in: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2024)
Our results suggest that the reduction of septal-to-lateral work imbalance by virtual pacing in the DT can predict real-world post-CRT LV reverse remodelling. This DT approach could prove to be an additional tool in selecting HF patients for CRT and has the potential to provide valuable insights in optimization of CRT delivery.
Keyphrases
- cardiac resynchronization therapy
- left ventricular
- heart failure
- hypertrophic cardiomyopathy
- end stage renal disease
- ejection fraction
- acute myocardial infarction
- newly diagnosed
- left atrial
- mitral valve
- aortic stenosis
- chronic kidney disease
- prognostic factors
- case report
- acute heart failure
- coronary artery disease
- human health
- percutaneous coronary intervention
- transcatheter aortic valve replacement