Rosa rugosa flavonoids alleviate myocardial ischemia reperfusion injury in mice by suppressing JNK and p38 MAPK.

Xuehui ZhangYuhui WangWanli ShenShangzhi MaWen ChenRong Qi

Published in: Microcirculation (New York, N.Y. : 1994) (2018)

RRF significantly inhibited MIRI through anti-oxidative, anti-inflammatory, and anti-apoptosis effects, and mechanisms were associated with its inhibition on phosphorylation of JNK and p38 MAPK.

Keyphrases

cell death
anti inflammatory
signaling pathway
induced apoptosis
endoplasmic reticulum stress
oxidative stress
cell cycle arrest
left ventricular
high fat diet induced
adipose tissue
cell proliferation
insulin resistance