Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model.
Yiannis PhilippouHanna T SjobergEmma MurphySaid AlyacoubiKeaton I JonesAlex N Gordon-WeeksSu PhyuEileen E ParkesW Gillies McKennaAlastair D LambUzi GileadiVincenzo CerundoloDavid A ScheiblinStephen J LockettDavid A WinkIan G MillsFreddie C HamdyRuth J MuschelRichard J BryantPublished in: British journal of cancer (2020)
3 × 5 Gy hypofractionated radiotherapy can result in tumour growth delay and immune cell changes in allograft prostate cancer models. Adjuncts beyond immunomodulation may be necessary to improve the radiotherapy-induced anti-tumour response.