Aptamer-Modified Tetrahedral Dna Nanostructures as Drug Delivery System for Cancer Targeted Therapy.
Ruirui ZhaoYunfeng BaiYujing GuoFeng FengShaomin ShuangPublished in: Macromolecular bioscience (2023)
Improving the selective delivery and uptake efficiency of chemotherapeutic drugs remains a challenge for cancer-targeted therapy. In this work, a DNA tetrahedron was constructed as a targeted drug delivery system for efficient delivery of doxorubicin (Dox) into cancer cells. The DNA tetrahedron was composed of a tetrahedral DNA nanostructure (TDN) with two strands of AS1411 aptamer as recognition elements which could target the nucleolin protein on the cell membrane of cancer cells. The prepared DNA tetrahedron had a high drug-loading capacity and demonstrated pH-responsive Dox release properties. This enabled efficient delivery of Dox into targeted cancer cells while reducing side effects on non-target cells. The proposed drug delivery system exhibited significant therapeutic efficacy in vitro compared to free Dox. Accordingly, this work provided a good paradigm for developing a targeted drug delivery system for cancer therapy based on DNA tetrahedrons. This article is protected by copyright. All rights reserved.
Keyphrases
- cancer therapy
- circulating tumor
- cell free
- single molecule
- drug delivery
- papillary thyroid
- nucleic acid
- gold nanoparticles
- circulating tumor cells
- induced apoptosis
- squamous cell
- squamous cell carcinoma
- oxidative stress
- wastewater treatment
- cell cycle arrest
- cell proliferation
- signaling pathway
- pi k akt
- magnetic nanoparticles
- lymph node metastasis
- electronic health record