Differences in histological features and PD-L1 expression between sporadic microsatellite instability and Lynch-syndrome-associated disease in Japanese patients with colorectal cancer.
Rin YamadaTatsuro YamaguchiTakeru IijimaRika WakaumeMisato TakaoKoichi KoizumiTsunekazu HishimaShin-Ichiro HoriguchiPublished in: International journal of clinical oncology (2018)
Therefore, compared with Lynch-syndrome-associated cancers, sporadic MSI cancers are more frequently solid, poorly differentiated medullary cancers that express PD-L1.