Integrated metagenomic and metabolomic analysis reveals distinctive stage-specific gut-microbiome-derived metabolites in intracranial aneurysms.

Haitao SunKaijian SunHao TianXiheng ChenShixing SuYi TuShilan ChenJiaxuan WangMeichang PengMeiqin ZengXin LiYunhao LuoYugu XieXin FengZhuang LiXin ZhangXifeng LiYanchao LiuWei YeZhengrui ChenZhaohua ZhuYouxiang LiFangbo XiaHongwei ZhouChuanzhi Duan

Published in: Gut (2024)

Our investigation highlights the potential of gut-microbiome-derived tryptophan metabolites as biomarkers for distinguishing RIA from UIA patients. The findings suggest a novel pathogenic role for gut-microbiome-derived IS in elastin degradation in the IA wall leading to the rupture of IA.

Keyphrases

end stage renal disease
ms ms
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
peritoneal dialysis
human health
microbial community