An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research.
Fa WangRobert L JohnsonPaul W SnyderMarsha L DeSmetJames C FleetPublished in: Digestive diseases and sciences (2015)
DSS-mediated epithelial damage induces a persistent, Cre-mediated recombination of floxed alleles in CAC mice. This enables the examination of gene function in colon epithelium during experimental colitis and colitis-induced colon cancer.