An Inducible, Large-Intestine-Specific Transgenic Mouse Model for Colitis and Colitis-Induced Colon Cancer Research.

Fa WangRobert L JohnsonPaul W SnyderMarsha L DeSmetJames C Fleet

Published in: Digestive diseases and sciences (2015)

DSS-mediated epithelial damage induces a persistent, Cre-mediated recombination of floxed alleles in CAC mice. This enables the examination of gene function in colon epithelium during experimental colitis and colitis-induced colon cancer.

Keyphrases

mouse model
high glucose
ulcerative colitis
diabetic rats
oxidative stress
dna damage
drug induced
type diabetes
genome wide
dna repair
gene expression
metabolic syndrome
adipose tissue
high fat diet induced
transcription factor