Diurnal range and intra-patient variability of ACTH is restored with remission in Cushing's Disease.
Reinier AlvarezElizabeth HoganDavid T AsuzuTianxia WuGloria OshegboRaven McGlottenMichaela CortesChristina HayesConstantine A StratakisChristina TatsiLynnette K NiemanPrashant ChittaboinaPublished in: The Journal of clinical endocrinology and metabolism (2023)
Our findings suggest that ACTH variability is suppressed in CD, and remission from CD is associated with the restoration of this variability. Furthermore, a decrease in plasma ACTH by 50% or more may serve as a predictor of remission post-TSS. These insights could guide clinicians in developing rational outcome measures for interventions targeting CD adenomas.