Association of a single nucleotide polymorphism in SOD2 with susceptibility for the development of diabetic nephropathy in patients with type 2 diabetes: A Saudi population study.
Samar SultanMeshari AlharbiNuha AlrayesNehad MakkiHanan FaruquiLama BasuniAmani AlhozaliReham AbdulnoorAnwar BoraiAbdullah AlmalkiAbdullah M AlzahraniReem AlamoudiMazin AlmaghrabiPublished in: Endocrinology, diabetes & metabolism (2023)
The findings of this study provide evidence that SOD2 rs4880 SNP may contribute to inadequate defence by the antioxidant enzyme, SOD2, against DM-induced oxidative stress and thus cause DN in Saudi patients with T2D. Therefore, SOD2 rs4880 may serve as a predictive marker to prevent the development and progression of DN in patients with T2D.