Comparative effectiveness of antibiotic therapy for carbapenem-resistant Enterobacterales (CRE) bloodstream infections in hospitalized US veterans.

Geneva M WilsonMargaret A FitzpatrickKatie J SudaBridget M SmithBeverly GonzalezMakoto JonesMarin L SchweizerMartin EvansCharlesnika T Evans

Published in: JAC-antimicrobial resistance (2022)

In hospitalized veterans with CRE-BSI, none of the treatments were shown to be associated with all-cause mortality. Ceftazidime/avibactam trended towards protectiveness against 30 day and 1 year all-cause mortality. Use of ceftazidime/avibactam should be encouraged for treatment of CRE-BSI.

Keyphrases

gram negative
multidrug resistant

klebsiella pneumoniae
escherichia coli

combination therapy
replacement therapy

smoking cessation