Pharmacogenetic Approach for the Prevention of Rivaroxaban's ADRs: A Systematic Review and Meta-Analysis.

Mahmood Bakhtiyari Bahareh AbbasiArman ShafieeTara Afsharmoghaddam

Published in: Genetics research (2023)

This study revealed that being an AC or CC for rs1045642 is attributed to a considerably higher rivaroxaban level in participants using rivaroxaban. That is to say, rs1045642 is a remarkable predictor of rivaroxaban metabolism. We concluded that identifying rs1045642 before drug administration might decrease ADRs although further studies adjusted for potential confounders are strongly suggested.

Keyphrases

venous thromboembolism
atrial fibrillation
pulmonary embolism
drug administration
single cell
risk assessment