Development of an age-adjusted model for blood neurofilament light chain.

Christopher T HarpGian-Andrea ThaneiXiaoming JiaJens KuhleDavid LeppertSabine SchaedelinPascal BenkertH-Christian von BüdingenRobert HendricksAnn Herman

Published in: Annals of clinical and translational neurology (2022)

A log-linear, age adjustment model was developed to enable comparison of NfL levels across populations with different ages. While additional data and evidence are needed for patient-level adoption, this could be a valuable tool for interpreting NfL levels across a range of patient groups with neurologic conditions.

Keyphrases

case report
electronic health record
big data
cerebrospinal fluid
machine learning
artificial intelligence