Developing an internal threshold of toxicological concern (iTTC).

Jon A ArnotLiisa TooseJames M ArmitageAlessandro SangionAlexandra LookyTrevor N BrownLi LiRichard A Becker

Published in: Journal of exposure science & environmental epidemiology (2022)

Existing Threshold of Toxicological Concern (TTC) approaches are limited in their applications for route-specific exposure scenarios only and are not suitable for chemical risk and safety assessments under conditions of aggregate exposure. New internal Threshold of Toxicological Concern (iTTC) values are developed to address data gaps in chemical safety estimation for multi-route and aggregate exposures.

Keyphrases

climate change
air pollution
oxide nanoparticles
big data
machine learning