Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice.

Yixiao XiongXin LiuLing JiangTao HaoYanyan WangTao Li

Published in: Journal of translational medicine (2024)

The present study contributes to a deeper understanding of the specific mechanisms by which ferroptosis is involved in the development of HFpEF and suggests that inhibition of ferroptosis may mitigate the progression of HFpEF. In addition, eleven hub genes were recognized as potential drug binding targets.

Keyphrases

cell death
bioinformatics analysis
genome wide
type diabetes
high fat diet induced
adipose tissue
climate change
skeletal muscle
dna binding
transcription factor
wild type
genome wide identification