Single-cell profiling reveals preferential reduction of memory B cell subsets in cladribine patients that correlates with treatment response.

Valerie E TeschnerAnn-Katrin FleckCarolin WalterAnna-Sophie SchwarzeMelanie EschbornTimo WirthOlga V SteinbergAndreas Schulte-MecklenbeckI-Na LuMarisol Herrera-RiveroClaudia JanoschkaJan D LünemannNicholas SchwabGerd Meyer Zu HörsteJulian VargheseCatharina C GrossRefik PulChristoph KleinschnitzSimone MaderEdgar MeinlMonika StollHeinz Wiendl Luisa Klotz

Published in: Therapeutic advances in neurological disorders (2023)

We describe a pronounced and sustained effect of cladribine on the memory B cell compartment, and the resulting change in B cell subset composition causes a significant alteration of B cell transcriptional profiles resulting in reduced proinflammatory and T cell activating capacities. The extent of reduction in selected memory B cell clusters by cladribine may predict treatment response.

Keyphrases

single cell
working memory
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
rna seq
prognostic factors
gene expression
signaling pathway
transcription factor