A Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics.
Yu-Jih SuFu-An LiJim Jinn-Chyuan SheuSung-Chou LiShao-Wen WengFeng-Chih ShenYen-Hsiang ChangHuan-Yuan ChenChia-Wei LiouTsu-Kung LinJiin-Haur ChuangPei-Wen WangPublished in: Cells (2022)
In this experiment, we confirmed that the B cells in the lupus murine model focusing on the TLR7 pathway were activated through the MDA5 signaling pathway, an important RNA sensor implicated in the detection of viral infections and autoimmunity. The MDA5 agonist/antagonist RNAs and the detailed molecular interactions within B cells are worthy of further investigation for lupus therapy.
Keyphrases
- systemic lupus erythematosus
- breast cancer cells
- disease activity
- mouse model
- signaling pathway
- cell cycle arrest
- label free
- rheumatoid arthritis
- sars cov
- toll like receptor
- immune response
- mass spectrometry
- inflammatory response
- high glucose
- cell death
- epithelial mesenchymal transition
- loop mediated isothermal amplification
- stem cells
- nuclear factor
- induced apoptosis
- cell proliferation
- cell therapy
- quantum dots
- endoplasmic reticulum stress
- smoking cessation