Immune Exhaustion of T Cells in Alveolar Echinococcosis Patients and Its Reversal by Blocking Checkpoint Receptor TIGIT in a Murine Model.

Chuanshan ZhangRenyong LinZhide LiShuting YangXiaojuan BiHui WangAbudusalamu AiniNing ZhangAbuduaini AbuliziCheng SunLiang LiZhibin ZhaoRongde QinXiaohong LiLiang LiTuerganaili AjiYingmei ShaoDominique A VuittonZhigang TianHao Wen

Published in: Hepatology (Baltimore, Md.) (2020)

This study demonstrates that E. multilocularis can induce T-cell exhaustion through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the functional impairment of T cells and represent a possible approach to immunotherapy against AE.

Keyphrases

end stage renal disease
dna damage
cell cycle
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
cell proliferation
patient reported outcomes