Electrically Controlled "Sponge Effect" of PEDOT:PSS Governs Membrane Potential and Cellular Growth.
Fabrizio AmoriniIsabella ZironiMarco MarzocchiIsacco GualandiMaria CalienniTobias CramerBeatrice FraboniGastone CastellaniPublished in: ACS applied materials & interfaces (2017)
PSS is a highly conductive material with good thermal and chemical stability and enhanced biocompatibility that make it suitable for bioengineering applications. The electrical control of the oxidation state of PEDOT:PSS films allows modulation of peculiar physical and chemical properties of the material, such as topography, wettability, and conductivity, and thus offers a possible route for controlling cellular behavior. Through the use of (i) the electrophysiological response of the plasma membrane as a biosensor of the ionic availability; (ii) relative abundance around the cells via X-ray spectroscopy; and (iii) atomic force microscopy to monitor PEDOT:PSS film thickness relative to its oxidation state, we demonstrate that redox processes confer to PEDOT:PSS the property to modify the ionic environment at the film-liquid interface through a "sponge-like" effect on ions. Finally, we show how this property offers the capability to electrically control central cellular properties such as viability, substrate adhesion, and growth, paving the way for novel bioelectronics and biotechnological applications.
Keyphrases
- atomic force microscopy
- room temperature
- ionic liquid
- perovskite solar cells
- high resolution
- single molecule
- induced apoptosis
- reduced graphene oxide
- quantum dots
- high speed
- hydrogen peroxide
- solid state
- cell cycle arrest
- mental health
- electron transfer
- nitric oxide
- endoplasmic reticulum stress
- signaling pathway
- risk assessment
- climate change
- microbial community
- amino acid
- dual energy
- structural basis
- electron microscopy
- cell adhesion