The Effect of Chirality on the Application of 5-[18F]Fluoro-Aminosuberic Acid ([18F]FASu) for Oxidative Stress Imaging.
Milena ČolovićHua YangHelen MerkensNadine ColpoFrançois BénardPaul SchafferPublished in: Molecular imaging and biology (2021)
Our data suggest that pure 2S-[18F]FASu can be used to noninvasively image system xC- in a variety of cancers, either as the racemic mixture (2S,5R/S-) or optically pure form. Furthermore, this work shows potential utility of [18F]FASu for detection of glioblastoma and prostate cancer.
Keyphrases
- prostate cancer
- oxidative stress
- radical prostatectomy
- high resolution
- electronic health record
- positron emission tomography
- deep learning
- dna damage
- loop mediated isothermal amplification
- ischemia reperfusion injury
- label free
- real time pcr
- induced apoptosis
- computed tomography
- young adults
- risk assessment
- signaling pathway
- data analysis
- photodynamic therapy
- endoplasmic reticulum stress
- sensitive detection
- childhood cancer