Single- versus Multi-Ancestry Polygenic Risk Scores for CKD in Black Americans.
Alana C JonesAmit PatkiVinodh SrinivasasainagendraHemant K TiwariNicole D ArmstrongNinad S ChaudharyNita A LimdiBertha A HidalgoBrittney H DavisJames J CiminoAtlas KhanKrzysztof KirylukLeslie A LangeEthan M LangeDonna K ArnettBessie A YoungClarissa Jonas DiamantidisNora FranceschiniSylvia Wassertheil-SmollerStephen S RichJerome I RotterJosyf C MychaleckyiHolly J KramerYii-Der Ida ChenBruce M PsatyJennifer A BrodyIan H de BoerNisha BansalJoshua C BisMarguerite R IrvinPublished in: Journal of the American Society of Nephrology : JASN (2024)
In this study, we developed a PRS that was significantly associated with CKD with improved predictive accuracy when including APOL1 risk status. However, PRS generated from multi-ancestry populations outperformed single-ancestry PRS in our study.
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