Increased Placental sFLT1 (Soluble fms-Like Tyrosine Kinase Receptor-1) Drives the Antiangiogenic Profile of Maternal Serum Preceding Preeclampsia but Not Fetal Growth Restriction.

Francesca Gaccioli Ulla Sovio Sungsam GongEmma CookDavid Stephen Charnock-Jones Gordon C S Smith

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

We conclude that the elevated sFLT1:PlGF ratio is primarily driven by increased placental sFLT1 in preeclampsia, whereas in FGR, it is primarily driven by decreased placental PlGF.

Keyphrases

tyrosine kinase
epidermal growth factor receptor
pregnancy outcomes
early onset
pregnant women
birth weight
binding protein
physical activity
weight gain
preterm birth