Hedycaryol - Central Intermediates in Sesquiterpene Biosynthesis, Part II.

The known sesquiterpenes that arise biosynthetically from hedycaryol are summarised. Reasonings for the assignments of their absolute configurations are discussed. The analysis provided here suggests that reprotonations at the C1=C10 double bond of hedycaryol are directed toward C1 and generally lead to 6-6 bicyclic compounds, while reprotonations at the C4=C5 double bond occur at C4 and result in 5-7 bicyclic compounds. Read more in the Review by H. Xu and J. S. Dickschat (DOI: 10.1002/chem.202200405).