Culturing with modified EGM2 medium enhances porcine neonatal islet-like cell clusters resistance to apoptosis in islet xenotransplantation.

Xiaoqian MaCejun YangJuan ZhangJia WangWei LiChang XuPengfei RongBin YeMinghua WuJianhui JiangShounan YiWei Wang

Published in: Xenotransplantation (2017)

Culturing NICC with EGM2 provides a simple and effective approach not only to increase NICC yield, viability, and maturation but also to enhance their resistance to apoptosis to preserve the initial graft mass for successful islet xenotransplantation.

Keyphrases

endoplasmic reticulum stress
oxidative stress
cell cycle arrest
cell death
single cell
cell therapy
stem cells
pi k akt