Comparing a novel machine learning method to the Friedewald formula and Martin-Hopkins equation for low-density lipoprotein estimation.
Gurpreet SinghYasin HussainZhuoran XuEvan SholleKelly MichalakKristina DolanBenjamin C LeeAlexander R van RosendaelZahra FatimaJessica M PeñaPeter W F WilsonAntonio M GottoLeslee J ShawLohendran BaskaranSubhi J Al'ArefPublished in: PloS one (2020)
An ML model was found to have a better correlation with direct LDL-C than either the Friedewald formula or Martin-Hopkins equation, including in the setting of elevated TG and very low LDL-C.