MIR137/MIR2682 locus is associated with perineural invasiveness in head and neck cancer.
Helena ČelešnikTomaž BüdefeldBogdan ČizmarevićMatija ŠvaganUroš PotočnikPublished in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2021)
The MIR137/MIR2682 locus correlated with HNSCC perineural invasiveness. This is the first report showing miR-2682 downregulation in head and neck cancer. Our results support the tumor suppressive role of miR-137 and miR-2682. The inverse correlation between CpG73 hypermethylation and disease-free survival suggests this epigenetic mark may have prognostic value in HNSCC.