Quantitative assessment of circulating tumor cells in cerebrospinal fluid as a clinical tool to predict survival in leptomeningeal metastases.

Maria DiazPriya SinghIvan S KotchetkovAnna SkakodubAlicia MengChristel TamerRobert J YoungAnne S ReinerKatherine S PanageasLakshmi V RamanathanElena Pentsova

Published in: Journal of neuro-oncology (2022)

Our data shows that CSF-CTCs quantification predicts survival in newly diagnosed LM, and outperforms neuroimaging. CSF-CTC analysis can be used as a prognostic tool in patients with LM and provides quantitative assessment of disease burden in the CNS compartment.

Keyphrases

circulating tumor cells
cerebrospinal fluid
newly diagnosed
circulating tumor
free survival
electronic health record
blood brain barrier
small cell lung cancer
machine learning
deep learning
data analysis