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Development and application of an elastic net logistic regression model to investigate the impact of cardiac substructure dose on radiation-induced pericardial effusion in patients with NSCLC.

Joshua S NiedzielskiXiong WeiTing XuDaniel R GomezZhongxing LiaoJames A BanksonStephen Y LaiLaurence E CourtJinzhong Yang
Published in: Acta oncologica (Stockholm, Sweden) (2020)
We developed and evaluated elastic net regression toxicity models of radiation-induced PCE. We found the model type that included cardiac substructure dose had superior predictive performance. A final toxicity model that included cardiac substructure dose metrics was developed and reported for comparison with external datasets.
Keyphrases
  • radiation induced
  • radiation therapy
  • left ventricular
  • small cell lung cancer
  • oxidative stress