Hydrodynamics-based liver transfection achieves gene silencing of CB1 using short hairpin RNA plasmid in cirrhotic rats.
Adriana Díaz-RiveraAlejandra Meza-RíosVictoria Chagoya de SánchezGabriela Velasco-LoydenLeonel García-BenavidesLuis F Jave-SuarezHugo Christian Monroy-RamirezArturo Santos-GarcíaJuan Armendáriz-BorundaAna Sandoval-RodriguezPublished in: PloS one (2020)
Hydrodynamics allows a hepatotropic and secure transfection in cirrhotic animals. The sequence of the shCB1-B carried in a plasmid or any other vector has the potential to be used as therapeutic strategy for liver fibrosis.