Intrinsic Adrenal TWIK-Related Acid-Sensitive TASK Channel Dysfunction Produces Spontaneous Calcium Oscillations Sufficient to Drive AngII (Angiotensin II)-Unresponsive Hyperaldosteronism.

Christina A GancaycoMolly R GerdingDavid T BreaultMark P BeenhakkerPaula Q Barrett Nick A Guagliardo

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

We provide proof of principle that spontaneous activity of zG cells within classic rosette assemblies evoked solely by a change in an intrinsic, dominant resting-state conductance can be a significant source of AngII-independent aldosterone production from native tissue.

Keyphrases

angiotensin ii
resting state
functional connectivity
angiotensin converting enzyme
vascular smooth muscle cells
induced apoptosis
cell cycle arrest
oxidative stress
working memory
endoplasmic reticulum stress
cell death
signaling pathway