A Quantitative Approach to the Prediction of Drug-Drug Interactions Mediated by Cytochrome P450 2C8 Inhibition.

Veronica Di PaoloFrancesco Maria FerrariItalo PoggesiLuigi Quintieri

Published in: Expert opinion on drug metabolism & toxicology (2021)

The approach may help to adapt dose regimens for CYP2C8 substrates when given in combination with CYP2C8 inhibitors and to map the potential DDIs of new molecular entities.

Keyphrases

high resolution
human health
high density
adverse drug
risk assessment
mass spectrometry
climate change