Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment.

Hideyuki MasuiKenji KawadaYoshiro ItataniHideyo HiraiYuki NakanishiYoshiyuki KiyasuKeita HanadaMichio OkamotoWataru HirataYasuyo NishikawaNaoko SugimotoTakuya TamuraYoshiharu SakaiKazutaka Obama

Published in: British journal of cancer (2024)

Dual blockade of CCR1 and CXCR2 pathways in myeloid cells could be an effective therapy against colorectal cancer.

Keyphrases

induced apoptosis
dendritic cells
cell cycle arrest
bone marrow
acute myeloid leukemia
regulatory t cells
endoplasmic reticulum stress
signaling pathway
stem cells
oxidative stress
cancer therapy
drug delivery
cell proliferation