Ischemia-reperfusion injury and ischemic post-conditioning in acute myocardial infarction: Lost in translation.
Gennaro GiustinoGeorge D DangasPublished in: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2019)
Ischemic post-conditioning (IPoC) has been proposed as a strategy to mitigate the risk of ischemia-reperfusion injury during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). In this comprehensive and updated meta-analysis of randomized controlled trials, IPoC during primary PCI for STEMI had no significant effect on all-cause mortality, re-infarction, or new-onset heart failure compared with no post-conditioning. Further strategies need to be prospectively evaluated to improve outcomes in patients with STEMI undergoing primary PCI.
Keyphrases
- percutaneous coronary intervention
- st elevation myocardial infarction
- acute myocardial infarction
- ischemia reperfusion injury
- st segment elevation myocardial infarction
- acute coronary syndrome
- antiplatelet therapy
- coronary artery disease
- coronary artery bypass grafting
- heart failure
- oxidative stress
- atrial fibrillation
- coronary artery bypass
- systematic review
- left ventricular
- skeletal muscle