Loss of E-cadherin Induces IGF1R Activation and Reveals a Targetable Pathway in Invasive Lobular Breast Carcinoma.
Ashuvinee ElangovanJagmohan HoodaLaura SavariauSusrutha PuthanmadhomnarayananMegan E YatesJian ChenDaniel D BrownPriscilla F McAuliffeSteffi OesterreichJennifer M AtkinsonAdrian V LeePublished in: Molecular cancer research : MCR (2022)
Overall, this suggests that these targets require further exploration in ILC treatment and that CDH1 loss may be exploited as a biomarker of response for patient stratification.