Dexmedetomidine Activates Akt, STAT6 and IRF4 Modulating Cytoprotection and Macrophage Anti-Inflammatory Phenotype Against Acute Lung Injury in vivo and in vitro.
Qian ChenZhigang QinYibing SunXiangfeng LiuAurelie Pac SooEnqiang ChangQizhe SunBin YiDong-Xin WangHailin ZhaoDaqing MaJian-Teng GuPublished in: Journal of inflammation research (2022)
Dex protected against LPS-induced lung injury and suppressed LPS-induced pulmonary inflammatory responses by attenuating the NLRP3 inflammasome activation and promoting anti-inflammatory M2 macrophage polarization.