Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer.
Xianbing ZhuZheng FuKendall DutchakAzadeh ArabzadehSimon MiletteJutta SteinbergerGeneviève MorinAnie MonastVirginie PilonTim KongBianca N AdamsErika Prando MunhozHannah J B HoseinTianxu FangJing SuYibo XueRoni F RayesVeena SangwanLogan A WalshGuojun ChenAbdel Razaq Ahmad A AlyasinJonathan D SpicerMorag ParkDavid DankortSidong HuangPublished in: Cancer research (2024)
The combination of cytostatic CDK4/6 and BRD4 inhibitors induces senescent cancer cells that are primed for activation of ferroptotic cell death by targeting GPX4, providing an effective strategy for treating cancer.