Discriminating MGMT promoter methylation status in patients with glioblastoma employing amide proton transfer-weighted MRI metrics.
Shanshan JiangQihong RuiYu WangHye-Young HeoTianyu ZouHao YuYi ZhangXianlong WangYongxing DuXinrui WenFangyao ChenJihong WangCharles G EberhartJinyuan ZhouZhi-Bo WenPublished in: European radiology (2017)
• APTw-MRI is applied to predict MGMT promoter methylation status in GBMs. • GBMs with unmethylated MGMT promoter present higher APTw-MRI than methylated GBMs. • Multiple APTw histogram metrics can identify MGMT methylation status. • Mean APTw values showed the highest diagnostic accuracy (AUC = 0.825).