Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells.

Sandeep KumarSunil Kumar SinghNavin ViswakarmaGautam SondarvaRakesh Sathish NairPeriannan SethupathiMatthew DormanSubhash C SinhaKent HoskinsGregory ThatcherBasabi RanaAjay Rana

Published in: Journal for immunotherapy of cancer (2021)

Together, these results demonstrate that MLK3 plays an important role in CD8+ T cell survival and effector function and MLK3-CD70 axis could serve as a potential target in cancer.

Keyphrases

papillary thyroid
regulatory t cells
squamous cell carcinoma
risk assessment
immune response
human health