Nano Zinc Oxide Green-Synthesized from Plumbago auriculata Lam. Alcoholic Extract.
Mina Michael MelkSeham S El-HawaryFarouk Rasmy MelekDalia Osama SalehOmar M AliMohamed A Ei RaeyNabil Mohamed SelimPublished in: Plants (Basel, Switzerland) (2021)
Zinc oxide nanoparticles (ZnO NPs) were synthesized by using an alcoholic extract of the flowering aerial parts of Plumbago auriculata Lam. Dynamic Light Scattering (DLS) revealed that the average size of synthesized ZnO NPs was 10.58 ± 3.350 nm and the zeta potential was -19.6 mV. Transmission electron microscopy (TEM) revealed that the particle size was in the range from 5.08 to 6.56 nm. X-ray diffraction (XRD) analysis verified the existence of pure hexagonal shaped crystals of ZnO nanoparticles with an average size of 35.34 nm in the sample, which is similar to the particle size analysis acquired by scanning electron microscopy (SEM) (38.29 ± 6.88 nm). HPLC analysis of the phenolic ingredients present in the plant extract showed that gallic acid, chlorogenic acid, and catechin were found as major compounds at concentrations of 1720.26, 1600.42, and 840.20 µg/g, respectively. Furthermore, the inhibitory effects of ZnO NPs and the plant extract against avian metapneumovirus (aMPV) subtype B were also investigated. This assessment revealed that the uncalcinated form of Nano-ZnO mediated by P. auriculata Lam. extract possessed a significant antiviral activity with 50% cytotoxic concentration (CC50) and 50% inhibition concentration (IC50) of 52.48 ± 1.57 and 42.67 ± 4.08 µg/mL, respectively, while the inhibition percentage (IP) was 99% and the selectivity index (SI) was 1.23.
Keyphrases
- oxide nanoparticles
- electron microscopy
- room temperature
- light emitting
- quantum dots
- oxidative stress
- photodynamic therapy
- reduced graphene oxide
- anti inflammatory
- visible light
- single cell
- liver injury
- gold nanoparticles
- high resolution
- simultaneous determination
- computed tomography
- drug induced
- high performance liquid chromatography
- contrast enhanced
- data analysis
- structural basis