Characterization of novel CTNNB1 mutation in Craniopharyngioma by whole-genome sequencing.

Juan HeZhen ZengYuelong WangJiaojiao DengXin TangFujun LiuJianhan HuangHongxu ChenRuichao LiangXin ZanZhiyong LiuAiping TongGang GuoJianguo XuXiaofeng ZhuLiangxue ZhouYong Peng

Published in: Molecular cancer (2021)

Whole genome landscape for CP was revealed by WGS analysis, and a novel mutation in the exon 3 of CTNNB1 was identified. This novel mutation activates Wnt-signaling pathway through increasing the stability of β-catenin. Our findings provided us with more comprehensive insight into the spectrum of genetic alterations in CP.

Keyphrases

signaling pathway
cell proliferation
epithelial mesenchymal transition
stem cells
pi k akt
single cell
gene expression
copy number
oxidative stress
induced apoptosis