Addition of probenecid to oral β-lactam antibiotics: a systematic review and meta-analysis.

Richard C WilsonPaul ArkellAlaa RiezkMark GilchristGraham WheelerWilliam HopeAlison H HolmesTimothy Miles Rawson

Published in: The Journal of antimicrobial chemotherapy (2022)

Probenecid-boosted β-lactam therapy is associated with improved outcomes in gonococcal disease. Pharmacokinetic data suggest that probenecid-boosted oral β-lactam therapy may have a broader application, but appropriately powered mechanistic and efficacy studies are required.

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