Hyperoxia-induced S1P1 signaling reduced angiogenesis by suppression of TIE-2 leading to experimental bronchopulmonary dysplasia.

Tara SudhadeviAnjum JafriAlison W HaPrathima BasaJaya M ThomasPanfeng FuKishore WaryDolly MehtaViswanathan NatarajanAnantha Harijith

Published in: Cell biochemistry and biophysics (2021)

HO induces S1P1 followed by reduced expression of angiogenic factors. Reduction of S1P1 signaling restores ANG-1/ TIE-2 signaling leading to improved angiogenesis and alveolarization thus protecting against HO-induced neonatal lung injury.

Keyphrases

high glucose
endothelial cells
diabetic rats
vascular endothelial growth factor
drug induced
pi k akt
cell proliferation
long non coding rna