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TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection.

Kathrin HeimBenedikt Bindernull SagarDominik WielandNina HenselSian Llewellyn-LaceyEmma GostickDavid A PriceFlorian EmmerichHildegard VingerhoetAnke R M KraftMarkus CornbergTobias BoettlerChristoph Neumann-HaefelinDietmar ZehnBertram BengschMaike HofmannRobert Thimme
Published in: Gut (2020)
Our data highlight TOX as biomarker specific for dysfunctional virus-specific CD8+ T cells in the context of an actively persisting infection.
Keyphrases
  • hepatitis b virus
  • oxidative stress
  • electronic health record
  • big data
  • machine learning
  • deep learning
  • drug induced