TREM2 mediates MHCII-associated CD4+ T cell response against gliomas.
Jiaying ZhengLingxiao WangShunyi ZhaoWenjing ZhangYuzhou ChangDale B BoscoTao HuangAastha DheerShan GaoShengze XuKatayoun AyasoufiRawan Al-KharbooshFangfang QiManling XieAaron J JohnsonHaidong DongAlfredo Quiñones-HinojosaLong Jun WuPublished in: Neuro-oncology (2023)
Our study unveiled a previously unrecognized protective role of tumor-myeloid TREM2. Specifically, we found TREM2 enhance the phagocytosis of tumor cells and promote an immune response by facilitating MHCII-associated CD4+ T cell responses against gliomas.