Preliminary evidence of a relationship between sleep spindles and treatment response in epileptic encephalopathy.

John R McLarenYancheng LuoHunki KwonWen ShiMark A Kramer Catherine J Chu

Published in: bioRxiv : the preprint server for biology (2023)

These findings confirm thalamocortical disruption in EE-SWAS, identify a mechanism through which benzodiazepines may support cognitive recovery, and introduce sleep spindles as a promising mechanistic biomarker to detect treatment response in severe epileptic encephalopathies.

Keyphrases

early onset
sleep quality
physical activity
depressive symptoms
drug induced