High-glucose mixed-nutrient meal ingestion impairs skeletal muscle microvascular blood flow in healthy young men.
Lewan ParkerDale J MorrisonAndrew C BetikKatherine Roberts-ThomsonGunveen KaurGlenn David WadleyChristopher S ShawMichelle A KeskePublished in: American journal of physiology. Endocrinology and metabolism (2020)
Oral glucose ingestion leads to impaired muscle microvascular blood flow (MBF), which may contribute to acute hyperglycemia-induced insulin resistance. We investigated whether incorporating lipids and protein into a high-glucose load would prevent postprandial MBF dysfunction. Ten healthy young men (age, 27 yr [24, 30], mean with lower and upper bounds of the 95% confidence interval; height, 180 cm [174, 185]; weight, 77 kg [70, 84]) ingested a high-glucose (1.1 g/kg glucose) mixed-nutrient meal (10 kcal/kg; 45% carbohydrate, 20% protein, and 35% fat) in the morning after an overnight fast. Femoral arterial blood flow was measured via Doppler ultrasound, and thigh MBF was measured via contrast-enhanced ultrasound, before meal ingestion and 1 h and 2 h postprandially. Blood glucose and plasma insulin were measured at baseline and every 15 min throughout the 2-h postprandial period. Compared with baseline, thigh muscle microvascular blood volume, velocity, and flow were significantly impaired at 60 min postprandial (-25%, -27%, and -46%, respectively; all P < 0.05) and to a greater extent at 120 min postprandial (-37%, -46%, and -64%; all P < 0.01). Heart rate and femoral arterial diameter, blood velocity, and blood flow were significantly increased at 60 min and 120 min postprandial (all P < 0.05). Higher blood glucose area under the curve was correlated with greater MBF dysfunction (R2 = 0.742; P < 0.001). Ingestion of a high-glucose mixed-nutrient meal impairs MBF in healthy individuals for up to 2 h postprandial.
Keyphrases
- blood flow
- high glucose
- blood glucose
- endothelial cells
- glycemic control
- skeletal muscle
- heart rate
- insulin resistance
- blood pressure
- contrast enhanced ultrasound
- type diabetes
- middle aged
- adipose tissue
- body mass index
- weight loss
- oxidative stress
- heart rate variability
- high fat diet
- metabolic syndrome
- physical activity
- mass spectrometry
- ultrasound guided
- acute respiratory distress syndrome
- atomic force microscopy
- high speed