Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity.
Johanna MatilainenViivi BergMaija VaittinenUlla ImpolaAnne-Mari MustonenVille MännistöMarjo MalinenVeera LuukkonenNatalia RossoTanja TurunenPirjo KäkeläSilvia PalmisanoUma Thanigai ArasuSanna P SihvoNiina AaltonenKai HärkönenAndrea CaddeoDorota KaminskaPäivi PajukantaMinna U KaikkonenClaudio TiribelliReijo KäkeläSaara LaitinenJussi PihlajamäkiPetteri NieminenKirsi RillaPublished in: Journal of translational medicine (2024)
We are the first to provide detailed FA profiles of human AT EVs. We report that AT EV secretion increases in human obesity, implicating their role in TAG transport and association with adverse metabolic parameters, thereby emphasizing their role in metabolic disorders. These findings promote our understanding of the roles that EVs play in human AT biology and metabolic disorders.