Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts.

Xiangnan ZhaoYue LiuPingping JiaHui ChengChen WangShang ChenHaoyan HuangZhibo HanZhong-Chao HanKrzysztof MaryczXiaoniao ChenZongjin Li

Published in: Stem cell research & therapy (2021)

CS hydrogel-encapsulated EVs could delay the skin aging processes by ameliorating the function of aging DFLs. Our results also highlight the potential of CS hydrogel-encapsulated EVs as a novel therapeutic strategy for improving aging skin to rejuvenation.

Keyphrases

wound healing
drug delivery
dna damage
endothelial cells
cancer therapy
human health
extracellular matrix