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Telomere erosion in Sjögren's syndrome: A multi-tissue comparative analysis.

Braxton NollFarah Bahrani MougeotMichael T BrennanJean-Luc C Mougeot
Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)
Patients with pSS exhibited significant telomere erosion in saliva DNA. Overexpression of ATM in LSGs could represent a compensatory response to telomere shortening. The role of LEF1 in telomere erosion remains to be elucidated.
Keyphrases
  • cell proliferation
  • dna damage
  • single molecule
  • rheumatoid arthritis
  • dna repair
  • cell free
  • oxidative stress
  • dna damage response
  • systemic lupus erythematosus
  • disease activity