Telomere erosion in Sjögren's syndrome: A multi-tissue comparative analysis.

Braxton NollFarah Bahrani MougeotMichael T BrennanJean-Luc C Mougeot

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2019)

Patients with pSS exhibited significant telomere erosion in saliva DNA. Overexpression of ATM in LSGs could represent a compensatory response to telomere shortening. The role of LEF1 in telomere erosion remains to be elucidated.

Keyphrases

cell proliferation
dna damage
single molecule
rheumatoid arthritis
dna repair
cell free
oxidative stress
dna damage response
systemic lupus erythematosus
disease activity