Single-cell and spatial transcriptomics reveal POSTN + cancer-associated fibroblasts correlated with immune suppression and tumour progression in non-small cell lung cancer.

Chao ChenQiang GuoYang LiuQinghua HouMengying LiaoYanying GuoYupeng Zang Fei WangHuanyu LiuXinyu LuanYanling LiangZhuojue GuanYanling LiHaozhen LiuXuan DongXiuqing ZhangJixian LiuQumiao Xu

Published in: Clinical and translational medicine (2023)

CAFs associated with cancer progression and poor clinical outcomes and may provide new insights on the treatment of NSCLC.

Keyphrases

single cell
rna seq
small cell lung cancer
high throughput
squamous cell
genome wide
advanced non small cell lung cancer
gene expression
extracellular matrix
dna methylation
childhood cancer
smoking cessation