Genome-wide analysis of DNA methylation in hypothalamus and ovary of Capra hircus.

Stefano FrattiniEmanuele CapraBarbara LazzariStephanie D McKayBeatrice CoizetAndrea TalentiDebora GroppettiPietro RiccaboniAlessandro PecileStefania ChessaBianca CastiglioniJohn L WilliamsGiulio PagnaccoAlessandra StellaPaola Crepaldi

Published in: BMC genomics (2017)

The comparison between transcriptome and methylome in hypothalamus and ovary showed that a higher level of methylation is not accompanied by a higher gene suppression. The genome-wide DNA methylation map for two goat organs produced here is a valuable starting point for studying the involvement of epigenetic modifications in regulating goat reproduction performance.

Keyphrases

genome wide
dna methylation
genome wide analysis
copy number
gene expression
single cell
transcription factor
rna seq